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The procedure is painless and typically completed within 10-15 minutes

This will largely depend on the target populationidiopathic PD versus specific phenotypes/genotypesbut in general, an inclusive approach would be desirableage, sex, ethnicitycomplemented by enrichment of specific treatment arms according to the compounds mode of action, to progress towards precision medicine [48, 49]

GLP-1 inhibits intestinal contractions through mechanisms that may involve the central nervous system via vagal pathways or direct action on central receptors [24], as well as the enteric nervous system by modulating neurotransmission through presynaptic receptors affecting nitric oxide release [25,26]

Further studies are warranted to evaluate potential effect modification of GLP-1RA use on prostate cancer risk according to age and CVD