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249 Nuclear STAT3-Y705 activates glycolysis and fatty acid oxidation (FAO) genes, while mitochondrial STAT3-S727 and acetylated STAT3-K685 impair oxidative phosphorylation by destabilizing electron transport chain (ETC) complexes, supporting leukemia stem cell dormancy and persistence
Buchanan ME, Davis RL
& Ciriolo, M
It not only serves as a major risk factor for chronic diseases such as cardiovascular disease and diabetes but also exacerbates these conditions, further complicating their management and outcomes
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