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Neuropsychopharmacology 38 , 16071608 (2013)
Clinical trial data for FDA-approved GLP-1 receptor agonists demonstrates: Significant weight reduction: Meaningful mean body weight reduction in trial participants (see FDA-approved labeling for specific approved products) Cardiorenal protection: Reduced risk of major adverse cardiovascular events and kidney disease progression Improved lipid profiles: Decreased triglycerides and increased HDL cholesterol Blood pressure reduction: Modest but clinically significant decreases in systolic blood pressure Reduced inflammation: Decreased inflammatory markers associated with metabolic syndrome Note: Clinical outcomes cited above reflect published trial data for FDA-approved GLP-1 receptor agonists
The commission's report says an organised network of individuals and companies are involved in distributing the substances, including online suppliers, anti-ageing clinics and medical practitioners
Sakurabayashi T, Takaesu Y, Haginoshita S et al (1999) Improvement of myocardial fatty acid metabolism through L-carnitine administration to chronic hemodialysis patients
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