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PDE1B is enriched in the medium spiny neurons (MSNs) of the direct pathway, while PDE10A is highly expressed in the MSNs of both the direct and indirect pathways (Lakics et al., 2010)
Instead, the authors showed that hyperosmotic shock leads to breakdown of sphingomyelin, accumulation of ceramide, and later on to PS exposure and cell shrinkage
This attraction of water provides the ability of the skin to create volume and provide structural support
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