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Furthermore, inflammatory cytokines induce the activation of indoleamine 2,3-dioxygenase (IDO), an enzyme that catalyzes the production of kynurenine from tryptophan, thereby reducing the alternative metabolic pathway that yields 5-HT (Raison et al., 2010
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Conceptually, eradication of persisters can be achieved either by directly targeting them or by reverting them to a metabolically active state, thereby making them vulnerable to antibiotics
These are the usual culprits
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