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Your provider may also evaluate for other contributing factors such as vitamin deficiencies (particularly B12, especially if you also take metformin, or iron, vitamin D), thyroid dysfunction, or medication interactions that could be addressed independently of semaglutide therapy
Growing body of evidence suggests that dysfunction of the GLP-1 pathway, which directly targets mitochondria and preserves mitochondrial functions, contributes to the pathophysiology of depression [86]
They often support the need for advanced treatments or referrals (like bariatric surgery)
Moreover, in view of the clinical importance of zinc in mediating ischemic injury, future investigation is warranted to develop more effective, potentially zinc-based therapies
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