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[52] GLP: Glucagon-like peptide, GLP-1 RA: Glucagon-like peptide 1 receptor agonist, GI: Gastrointestinal Implications of GLP-1RA in critical care The action of GLP-1 agonists can have significant implications for the management of critically ill patients in terms of gastric emptying, tolerance of enteral nutrition, and glycaemic control
12-14 In phase III clinical studies in which exenatide was administered concomitantly with metformin, an SU, or metformin plus an SU, 48% of the 483 patients receiving exenatide 10 mcg twice daily reported nausea compared to 18% of the 483 patients receiving placebo
However, tirzepatide makes an additional hydrogen bond with and arginine residue (R190) in the GIP receptor, which is hypothesized to facilitate changes in G protein binding affinity and signaling (Sun et al., 2022)
The GLP-1 receptor is widely distributed in key emotional regulation brain regions such as the limbic system, prefrontal cortex and hypothalamus [30, 31]
