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In older adults, lifestyle modifications remain a significant challenge [11, 20], and the increasing burden of NCDs further underscores the strategic role of pharmacotherapy as part of a comprehensive strategy of the obesity management

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A body of evidence has indicated that IR is closely related to the occurrence and development of hypertension (110)

If true lymphadenopathy occurs during tirzepatide treatment, it should be evaluated independently as it may indicate an unrelated condition such as infection, inflammatory process, or other medical concern requiring investigation