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These include medications like semaglutide (brand names Ozempic and Wegovy ) and tirzepatide ( Mounjaro/Zepbound ), and they work very differently

There is limited data on its use during pregnancy and breastfeeding

Metformin, SLGT-2 inhibitors (examples include empagliflozin, dapagliflozin), GLP-1 receptor agonists (examples include semaglutide, liraglutide), and insulin are generally safe to take with grapefruit

Other considerations requiring monitoring include: pancreatitis, gallbladder problems (cholelithiasis), hypoglycemia when used with insulin or sulfonylureas, acute kidney injury, and diabetic retinopathy in patients with type 2 diabetes