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In contrast to the enhancement of spontaneous excitatory postsynaptic transmission (Mietlicki-Baase et al., 2013), using retrograde labeling of VTA to nucleus accumbens (NAc) medial shell projecting neurons, in vitro patch-clamp recordings showed that exendin-4 selectively inhibits the miniature excitatory postsynaptic currents (mEPSCs) within the dopaminergic VTA-to-NAc projection neurons (Wang et al., 2015
Mounjaro is a tirzepatide drug, but it belongs to the same class of drugs as semaglutide drugsGLP-1
Most patients begin noticing appetite reduction and early weight loss within 2-4 weeks of starting GLP-1 medications, with steady weight loss continuing over 12-18 months as medication doses are gradually increased to optimal therapeutic levels
Secondo NANOS e AAO la diagnosi di NAION durante terapia con GLP-1 AR non impone automaticamente la sospensione del farmaco
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