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Additional roles of ALDH2: In addition to breaking down alcohols, ALDHD also metabolizes:[ref] Retinol (vitamin A) Bile acids lipid peroxidation products neurotransmitter metabolites Studies link genetic variants in ALDH2 to increased risk of Alzheimers disease, possibly due to the decreased ability to break down lipid peroxidation products in the brain
It also provides antioxidant protection by neutralizing free radicals produced as a result of oxidative and metabolic stress
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The clinicopathological characteristics of patient samples are provided in Supplementary Table S1 for BS-PCR sequencing study and in Supplementary Table S2 for qMSP PCR assay
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