Short-Term Use, Long-Term Impact The study found that a large share of users 90% of those who discontinued GLP-1 use were on the medication for less than one year
Common side effects for both: Nausea (most common, improves over time) Diarrhea or constipation Vomiting (less common) Abdominal pain or bloating Reduced appetite (this is intended, but can be extreme) Fatigue, especially in first month Managing GI side effects: Eat smaller, more frequent meals Avoid fatty, greasy, or spicy foods Stay hydrated Don't lie down immediately after eating Consider anti-nausea medication if severe Most side effects peak in weeks 2-4 of each new dose, then improve significantly
Senekowitsch, S., Wietkamp, E., Grimm, M., Schmelter, F., Schick, P., Kordowski, A., Sina, C., Otzen, H., Weitschies, W., & Smollich, M
Many people use it indefinitely for weight maintenance