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These molecular vulnerabilities have spurred development of targeted therapeutics, with iron chelators (deferiprone), GPX4 stabilizers (Liproxstatin-1), and lipid antioxidant nanoparticles demonstrating 3050% neuroprotection in Parkinsons and Alzheimers models by specifically counteracting the three susceptibility factors

In addition, the pleiotropic physiological effects of carnitine (e.g., antioxidant, anti-inflammatory and antiapoptotic effects) are particularly important for the protection against kidney diseases, especially drug-induced nephrotoxicity [259]

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