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However, development was discontinued in 2007 after the largest Phase IIb trial failed to demonstrate statistically significant weight loss compared to placebo
This means that even twice-daily dosing leaves long windows without measurable peptide
The sponsor described the safety profile as comparable with the broader GLP-1 receptor agonist class
2025 Apr 7, Volume 12, Page 1538472 (4) M Riessland and ME Orr (2023) Translating the Biology of Aging into New Therapeutics for Alzheimers Disease: Senolytics The Journal of Prevention of Alzheimers Disease, Volume 10, Issue 4, November 2023, Pages 633-646
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