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Strategy #3: Pre-Treat the Area with Benadryl Cream Heres what you should do: Fill the syringe and bring it to room temperature (15-30 minutes before injection, as cold solutions increase pain) Apply Benadryl cream to the chosen injection site Wait one minute for the topical antihistamine to penetrate Clean the site with alcohol swab and inject through the treated area The Benadryl acts to create localized antihistamine environment that blunts mast cell degranulation

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The immune system generates massive amounts of reactive oxygen species (ROS) as chemical weapons against the invading pathogen