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SURPASS-4 is the largest and longest trial in the SURPASS project so far, and it is also the fifth and last completed global registration study on tirzepatide for the treatment of type 2 diabetes

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"FDA-approved medications undergo rigorous clinical trials with thousands of participants to establish safety and efficacy, while compounded versions lack this comprehensive regulatory oversight ." FDA Guidelines, 2024 What Zepbound's Clinical Trials Actually Demonstrated The SURPASS clinical trials showed that participants taking tirzepatide achieved an average weight loss of 15% to 22.5% of their starting body weight, depending on dosage

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The incidence of MTC in the United States is 0.22/100,000

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