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Graefe-Mody U, Friedrich C, Port A, Ring A, Retlich S, Heise T, Halabi A, Woerle HJ

Signalling from L-cells to sensory neurones in intact colon To examine whether L-cell-released ATP triggers afferent nerve signalling within the intact gut, we measured changes in mesenteric nerve activity from the proximal colon following AngII mediated L-cell activation

Banned methods include blood transfusions, blood doping, and artificial chemicals that enhance oxygen transport

That matters because tolerability tracks the size of the swing during starts, dose jumps, missed doses and restarts, while at stable maintenance it tracks average concentration which splitting leaves unchanged by design