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Targeted immunomodulators (TIMs) treat a wide range of autoimmune disorders, from rheumatoid arthritis and psoriasis to inflammatory bowel diseases
Clinical trials indicate that patients with type 2 diabetes experience less weight loss than those who are obese (non-diabetic)
Moderate : changes in fat mass, lean mass, selected metabolic markers
Collectively, these PK features create mismatches between mechanistic antioxidant promises and clinical efficacy, especially when ascent is rapid and symptom onset precedes peak systemic levels
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