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GLP-1 RAs, Glucagon-like Peptide-1 Receptor Agonists
Glucagon-like peptide 1 (GLP1) is a hormone primarily released from the gastrointestinal tract in response to food intake which controls insulin secretion and body weight through activation of its receptor (GLP1R) located in both pancreatic cells and in several brain nuclei
The Milken Institute's geographic mapping of Phase 2 and 3 trial sites found that counties more than 60 miles from a trial site tend to have lower incomes and education levels, less internet access, and higher rates of disability, and that agricultural counties and American Indian reservations are disproportionately far from trial access points ( [89] )
Research suggests that approximately 25% to 40% of weight loss during GLP-1 therapy may come from lean mass
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