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Pro-inflammatory factors such as interleukin-1 (IL-1), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-) are regarded as depression biomarkers (Carniel and da Rocha, 2021)
Therefore both GST and efflux pumps overexpression may confer high levels of resistance to the cytotoxic action of several antineoplastic drugs
Glutathione reductase (GR) and NADPH are then used to regenerate GSH
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