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A study of more than 600,000 veterans followed for up to three years found that those who started taking a GLP-1 drug for diabetes were about 15% to 20% less likely to misuse substances ranging from alcohol to opioids
Patients should understand that results develop gradually
However, endogenous GLP-1 is also produced by preproglucagon (PPG) neurons in the brain (Mller et al., 2019)
Complementary approaches such as siRNA-mediated NNMT knockdown, shRNA-mediated knockdown, CRISPR-based perturbation, or comparison with a structurally distinct NNMT inhibitor can help determine whether an observed phenotype follows NNMT biology rather than an unrelated chemical or solvent-associated effect
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