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Clin Pharmacol (2014) 6:1619.10.2147/CPAA.S70707 71 DaidoneFMontioliRPaiardiniACelliniBMacchiaruloAGiardinaGet alIdentification by virtual screening and in vitro testing of human DOPA decarboxylase inhibitors
The full mass scan was acquired from m/z 350 to 1550 with resolution 120,000 at a target of 2e5 ions, and the MS/MS spectra were obtained in a data dependent acquisition in the top speed mode with higher-energy collision dissociation (target 5e4 ions, max ion injection time 100 ms, isolation window 1.6 m/z , normalized collision energy 25%)
Given the complex and interconnected nature of oxidative stress and its downstream effects, exploring multi-target combination therapy regimens may be more effective than single-target approaches, aiming for synergistic effects on the oxidative storm and its consequences
Dissecting molecular cross-talk between Nrf2 and NF- B response pathways
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