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doi: 10.3724/zdxbyxb-2022-0328 100 ZhangJ
GLP-1/GIP mechanisms Investigations into hepatic metabolism and energy expenditure Research protocols designed around Chinese clinical trial data When to consider Tirzepatide: Studies requiring FDA-approved compound status Research replicating established SURMOUNT/SURPASS protocols Investigations into dual incretin (GLP-1 + GIP) signaling Protocols requiring extensive published reference literature When to consider Retatrutide: Studies examining comprehensive multi-receptor activation Research comparing triple vs
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Its three FDA approvals, proven cardiovascular benefit in the SELECT trial, oral formulation option, and extensive post-marketing data make it the reference against which all next-generation compounds must be measured
