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Endothelial migration and angiogenesis research forms a second major application area, with scratch-wound assays, capillary tube-formation assays, and other in vitro preparations characterising combination effects across multiple model systems
therefore, nutritional deficiency of this vitamin is rare in adults in the absence of malabsorption disorders
They can support mechanistic hypotheses about endothelial response and microvascular repair, but they do not establish human wound healing efficacy, cardiovascular benefit, clinical safety, or suitability for any condition where abnormal angiogenesis could be biologically relevant
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