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The formulation integrates three mechanistically distinct peptides that are frequently examined in regenerative and cytoprotective research models
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However, in a randomized phase III double-blind clinical trial, tivantinib did not improve OS time in patients with Met-high advanced HCC treated with sorafenib compared with placebo (Rimassa et al., 2018) (NCT01755767)
The starting dose of 0.3 mg represents approximately 6.7% of the final maintenance dosea conservative approach that prioritizes safety
