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Other randomized clinical trials, whose main objective was to reduce macro and microvascular outcomes, were conducted, such as the ACCORD study (Action to Control Cardiovascular Risk in Diabetes) [38], ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation) [39] and the VADT (Veterans Affair Diabetes Trial) [40]

Your prescriber will outline the titration schedule usually starting at 0.25mg/week for the first 4 weeks before escalating

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Pharmacokinetics of nanoscale quantum dots: in vivo distribution, sequestration and clearance in the rat