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Despite this promise, several critical limitations remain: No large-scale, randomized controlled human trials to confirm efficacy, safety, or long-term impact Toxicology and pharmacokinetic data are lacking, especially for chronic use or high-dose regimens Only one stereoisomer (all-L form) has been tested
However, PEGylation can also change tissue distribution, binding, formulation behavior, and immune recognition, so half-life assumptions for PEG-MGF cannot be treated as clinical proof [13] [15]
Li, Q., Han, Y., Dy, A
10.1016/j.nicl.2022.103152 58
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