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Especially in PDLSC, Ex-4 has also proven to activate MAPK and WNT-signaling [19, 21, 24] as well as Hedgehog/Gli1-1 and nuclear factor kappa B (NF-B) signaling, thus promoting osteogenic differentiation [15, 17, 21, 24, 26, 38]

Epithalon is a synthetic tetrapeptide composed of these four amino acids: alanine (Ala) glutamic acid (Glu) aspartic acid (Asp) glycine (Gly) It is also known as epitalon and AEDG (the abbreviations for its amino acid content)