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Vitamin B-12 is used in the metabolism of fats, carbohydrates, and proteins, and is also required for fatty acid synthesis
In its oxidized (NAD+) and reduced (NADH) forms, this coenzyme cycles between metabolic reactions, accepting and donating electrons during nutrient breakdown and ATP generation
But here is where things get complicated
For mitochondrial metabolism and mitochondrial biogenesis, as shown in Figure 4, there are two mechanisms originating from the AMPK/SIRT1/PGC1- signaling pathway
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