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Elevated MMA may result from impaired absorption, increased oxidative degradation, or functional enzymatic limitations 40,41
i Remien CH, et al
Using C2C12 mouse myoblasts, the study confirmed that the MGF E-domain peptide increases myoblast proliferation while inhibiting terminal differentiation and critically, that this effect was maintained in the presence of a neutralising anti-IGF-1R antibody directly establishing that MGF E-peptide signals via an IGF-1R-independent mechanism
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