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p = 0.001) compared with sitagliptin (43)
Organ and tissue growth concerns Because IGF-1 signaling affects cellular growth and proliferation throughout the body and not exclusively in skeletal muscle, there is concern that long-term use of IGF-1 could result in increased growth of other tissues/organs in the body
Semaglutide met all primary endpoints and, if the rest of the study proceeds as expected, is about to be extended
However, the delayed gastric emptying caused by Wegovy could theoretically affect the absorption of some oral medications, particularly those with a narrow therapeutic index, though this has not been specifically identified as a concern with sertraline
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