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When encountering the latter, it is known to secrete a multitude of proteases 9,10
Through Nrf2 signaling and immune modulation, the ozone-oxygen therapy stimulates glutathione production and nudges the mitochondrial function back to normal
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These pathways not only preserve proteome integrity but also offer powerful therapeutic opportunities, as demonstrated by the emergence of proteasome inhibitors, autophagy modulators, and molecular chaperone-targeting agents in clinical medicine (Tables 1 and 2)
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