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Although a direct causal link between NAD+ supplementation and cancer progression has not been proven, experts recommend that patients with an ongoing cancer or a history of cancer only consider NAD+ therapy with clearance from their oncologist

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But that peripheral-only action means it does not suppress appetite, does not change energy expenditure through central pathways, and does not produce the dramatic caloric deficits that GLP-1 agonists like semaglutide or tirzepatide create

NNMT Inhibitors as a Therapeutic Option for Metabolic Disorders. Journal of Medicinal Chemistry Policarpo, R., et al