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In an in vitro study by Zhao et al., liraglutide reduced cell proliferation and increased cell apoptosis in estrogen receptor-positive breast cancer cells (Zhao et al., 2018)
In addition to that, DPP-4 enzyme also deactivates more than 40 physiologically active hormones, neuropeptides, cytokines, and other proteins in vivo through dipeptide cleavage (Mentlein et al., 1993)
The profile is largely consistent with the established GLP-1 RA class, characterized primarily by manageable gastrointestinal side effects, but also includes specific warnings and precautions that require careful clinical attention and patient counseling
