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374 Cytotoxicity to normal cells is one of the reasons for the omission of SAH-p53-8 in clinical trials

doi: 10.2337/db19-0756 121 OresicMSimellSSysi-AhoMNnt-SalonenKSeppnen-LaaksoTParikkaVet al

[1] The honest summary is that the animal record is heterogeneous: some biomarkers move favorably in some strains and protocols, but a clean, reproducible, cross-laboratory lifespan-extension signal is not established, and the variability across experiments is itself a reason for caution rather than a footnote to be skipped

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