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Currently, there are two main types of drug therapy used to treat melanoma: Targeted therapy BRAF inhibitors: dabrafenib and vemurafenib MEK inhibitors: trametinib Combination BRAF and MEK inhibitors: dabrafenib C-KIT inhibitors: imatinib, nilotinib Immunotherapy/immune-modulating therapy PD-1 antagonist: pembrolizumab and nivolumab PD-L1: atezolizumab CTLA-4 antagonist: ipilimumab LAG-3 inhibitor: relatlimab Interleukin-2 (IL-2) Interferon alfa 2b Chimeric antigen receptor T cell therapy (CAR-T) Imiquimod Oncolytic virus - Talimogene laherparepvec (Imlygic) For a more detailed summary of the immunotherapy agents currently available, see the Cancer Research Institute website

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