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This effect is dose-dependent and may diminish with continued use Central appetite regulation : They act on receptors in the hypothalamus and other brain regions to reduce appetite and food intake Most GLP-1 agonists are administered via subcutaneous injection, with dosing frequencies ranging from once daily to once weekly depending on the specific agent

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When your stomach empties more slowly, hunger returns much later

Clinical reports and case series have documented instances of retained gastric contents found during anaesthetic induction in patients taking GLP-1 medications who had followed standard fasting instructions