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These individual unimolecular multi-agonists activities seemed to harmonize the overall metabolic efficacy, which predominantly results from synergistic glucagon action to increase energy expenditure, GLP-1 action to reduce caloric intake and improve glucose control, and GIP action to potentiate the incretin effect and buffer against the diabetogenic effect of inherent glucagon activity

Approaches to oral delivery include oral small molecules and oral peptides

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Until such trials are completed and published, retatrutides role in PCOS insulin resistance remains a well-motivated but unproven hypothesis