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A microbiome-based random forest classifier was therefore constructed to predict the TMAO producer phenotype (AUROC = 0.81) which was then validated with an external cohort (AUROC = 0.80)

Metabolomic studies in the preclinical ischemic AKI model have shed substantial light on this issue and demonstrated widespread changes in energy metabolism in the kidney as well as remote organs including the heart and lung 6,15, 16

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