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First of all, a robust framework for ex vivo manipulation with patients cells should be created, which significantly complicates the therapeutic conditions and increases the final cost of this therapy

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In murine models of obesity and diabetes, administration of the chemical chaperones phenyl butyric acid (PBA) and tauro-ursodeoxycholic acid (TUDCA), increased systemic insulin sensitivity, established normoglycemia, reduced fatty liver disease, and suppressed inflammatory signaling (137)