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This combination makes it relevant not just for aesthetic outcomes but for the broader inflammatory burden that accelerates aging in metabolically active tissues

Randomized controlled trials The double-blind, placebo-controlled Nutritional Prevention of Cancer (NPC) study in 1,312 older adults with a history of nonmelanoma skin cancer found that supplementation with 200 g/day of selenium-enriched yeast (selenized yeast) for an average of 7.4 years resulted in a 52% decrease in prostate cancer incidence in men (81)

Vegans and "patients with diseases like Crohn's and colitis as well as people with pernicious anemia are also particularly vulnerable to deficiency," added Silverstein

Disruptions to this equilibrium can lead to oxidative stress, mitochondrial dysfunction, and aberrant energy metabolism [150]