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Based on the findings, GLP-1RAs are evolving into multisystem therapies with expanding roles beyond diabetes, including cardiovascular, renal, and hepatic benefits, as well as potential neurocognitive benefits

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The estimated mean within-subject day-to-day variability in AUC 024 h,semaglutide,SS and C max,semaglutide,SS ranged between 19.7% and 34.9% across the three treatment groups, while the total variability (which consists of both the within-subject day-to-day variability and the between-subject variability) ranged between 63.6% and 84.4% (electronic supplementary Table S8)

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