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doi: 10.7759/cureus.64738

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However, studies have shown that consistent use over 2-3 months can lead to mild skin brightening effects and may help lighten superficial pigmentation

[13] One Dutch study found that after adjustment for gender and age, there was a statistically significant negative association between the use of metformin and vitamin D status, with those who did not use a vitamin D supplement having levels of vitamin D 14.4 percent lower than controls

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