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B12 is water-soluble and any excess is excreted in urine there is no established upper tolerable intake level for B12 and toxicity from injection at standard doses has not been reported
In the 72-week non-diabetic obesity trial, adults lost -15.0% at 5 mg, -19.5% at 10 mg, and -20.9% at 15 mg. Real-world outcomes vary because dose reached, adherence, and baseline state vary
In 2024, private B12 injections average 30-60 per dose
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