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Yet there is currently only one FDA-approved adjunctive therapy for type 1: Symlin (pramlintide), a drug that is rarely used due to its long list of side effects
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As deletion of GLR1 would not be expected to decrease NADPH levels, these assays support the hypothesis that matrix glutathione oxidation specifically is detrimental for cell fitness
A Phase 1 study of healthy volunteers conducted in Europe has completed enrollment, with a total of 201 subjects enrolled
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