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ROS Overproduction: The Initiating Driver Hyperglycaemia activates multiple simultaneous ROS sources, including mitochondrial uncoupling, NADPH oxidase isoforms NOX2 and NOX4, and xanthine oxidase upregulation
Louis, MO: Mosby, 2001
While these side effects are typically dose-related and often fade over time, they remain the leading reason for early drop-out from clinical trials
Moreover, their expression was positively correlated with that of fibronectin, an ECM protein
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