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however, in vivo, one could imagine that repeated 5FU exposures would drive selection of pre-existing niches of tumours cells that had higher mitochondrial functionality
For instance, MPTPs selective destruction of dopaminergic neurons via mitochondrial complex I inhibition is a well-documented cause of drug-induced parkinsonism
Moving forward, robust longitudinal clinical studies, mechanistic elucidation, and personalized microbiome profiling will be critical to transforming this emerging science into actionable therapies for neurodegenerative disease
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