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This fundamental shift explains why many users describe the experience as effortless compared to previous weight loss attempts

Secondary benefits include cardiovascular health and risk reduction of major adverse cardiovascular events

This is best achieved with either MDI of subcutaneous basal insulin analogues and mealtime rapid-acting or ultra-rapid-acting insulin analogues, or with continuous subcutaneous insulin infusion of a rapid-acting insulin analogue via a pump, delivered as continuous basal insulin combined with manual mealtime boluses

These differences are usually minor and resolve within one to two injection cycles