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This transition involves upregulation of markers such as CD206, Arg1, and IL-10, enhanced efferocytosis of apoptotic cells, and secretion of growth factors like VEGF, TGF-, and FGF2, which promote angiogenesis, fibroblast activation, and ECM remodeling [41]
10.2165/00151829-200504030-00003 Treat Respir Med
PMC6073405 BPC-157 angiogenic signaling VEGFR2-Akt-eNOS activation, nitric oxide bioavailability, FAK-paxillin cell-anchoring cascade, anti-cytokine modulation: PMC8275860 TB-4 / TB-500 G-actin sequestration and threshold-saturation mechanism actin-monomer binding, cytoskeletal mobilization for cell migration, mass-action pharmacodynamics requiring bolus dosing: PubMed 12581423 TB-4 Ac-SDKP anti-fibrotic fragment N-terminal tetrapeptide (fragment 14) released by meprin- and POP processing
This animal model also demonstrates a unique pattern of elevations in short-chain and long-chain acyl-carnitines suggesting abnormalities in fatty-acid metabolism
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