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Patient data for the study was provided by the US National Institutes of Health All of Us Research Program, one of the largest and most diverse health databases in the USA
Validation of the above analysis further confirmed the lack of evidence of an association between GLP-1RAs and SSIBs
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Moreover, liraglutide elicited a phenotypic shift in macrophages from proinflammatory M1 to anti-inflammatory M2, while also inhibiting the expression of enzymes implicated in cartilage degradation
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